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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUCY2F
All Species:
11.82
Human Site:
S706
Identified Species:
26
UniProt:
P51841
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51841
NP_001513.2
1108
124822
S706
R
L
S
E
E
E
S
S
M
E
E
L
L
W
T
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001098846
1108
125126
C706
R
L
S
E
G
E
S
C
V
E
E
L
L
W
T
Dog
Lupus familis
XP_538138
1108
124925
S706
R
L
S
Q
E
E
P
S
A
E
E
L
L
W
T
Cat
Felis silvestris
Mouse
Mus musculus
Q5SDA5
1108
124407
S706
R
L
S
E
E
E
P
S
E
E
E
L
L
W
T
Rat
Rattus norvegicus
P51842
1108
124393
S706
R
L
S
E
E
E
P
S
E
E
E
L
L
W
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506097
1100
119406
P727
R
A
P
R
P
Q
P
P
S
E
E
L
L
W
T
Chicken
Gallus gallus
XP_417281
1078
121075
P678
K
C
P
Y
V
Q
P
P
P
E
E
L
L
W
T
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001103165
1107
124634
P706
R
F
P
Y
I
E
P
P
A
E
D
L
L
W
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q07553
1163
130896
E687
Q
E
E
P
N
K
S
E
L
E
L
K
R
A
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09435
1137
128085
L719
Q
T
P
P
K
K
R
L
L
W
V
A
P
E
V
Sea Urchin
Strong. purpuratus
P16065
1125
126238
G728
Q
K
Q
D
V
D
L
G
D
H
A
K
L
A
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
97.5
91.4
N.A.
89.9
89.8
N.A.
51.3
60.7
N.A.
61.9
N.A.
31.5
N.A.
29.5
32.5
Protein Similarity:
100
N.A.
98.1
94.7
N.A.
93.7
93.5
N.A.
67.2
75
N.A.
75.9
N.A.
48.6
N.A.
47.9
50.4
P-Site Identity:
100
N.A.
80
80
N.A.
86.6
86.6
N.A.
46.6
40
N.A.
46.6
N.A.
13.3
N.A.
0
6.6
P-Site Similarity:
100
N.A.
86.6
86.6
N.A.
86.6
86.6
N.A.
53.3
53.3
N.A.
53.3
N.A.
33.3
N.A.
26.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
0
0
0
0
19
0
10
10
0
19
0
% A
% Cys:
0
10
0
0
0
0
0
10
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
10
0
10
0
0
10
0
10
0
0
0
0
% D
% Glu:
0
10
10
37
37
55
0
10
19
82
64
0
0
10
0
% E
% Phe:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
10
0
0
10
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% H
% Ile:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
10
10
0
0
10
19
0
0
0
0
0
19
0
0
0
% K
% Leu:
0
46
0
0
0
0
10
10
19
0
10
73
82
0
10
% L
% Met:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
37
19
10
0
55
28
10
0
0
0
10
0
0
% P
% Gln:
28
0
10
10
0
19
0
0
0
0
0
0
0
0
0
% Q
% Arg:
64
0
0
10
0
0
10
0
0
0
0
0
10
0
10
% R
% Ser:
0
0
46
0
0
0
28
37
10
0
0
0
0
0
0
% S
% Thr:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
73
% T
% Val:
0
0
0
0
19
0
0
0
10
0
10
0
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
10
0
0
0
73
0
% W
% Tyr:
0
0
0
19
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _